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Health:Alternative Health A to Z:N:Nu:Nucleoside Analogues
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Didanosine
<P><B><FONT SIZE=+1>DESCRIPTION</FONT></B> <p></P> <table border="5" cellpadding="3" align="center" bgcolor="#FFFFDD" width="90%"> <tr> <td height="250" valign="top" align="left" width="607"> <P align="center"><b>WARNING </b> </P> <P>FATAL AND NONFATAL PANCREATITIS HAS OCCURRED DURING THERAPY WITH VIDEX USED ALONE OR IN COMBINATION REGIMENS IN BOTH TREATMENT-NAIVE AND TREATMENT-EXPERIENCED PATIENTS, REGARDLESS OF DEGREE OF IMMUNOSUPPRESSION. VIDEX SHOULD BE SUSPENDED IN PATIENTS WITH; SUSPECTED PANCREATITIS AND DISCONTINUED IN PATIENTS WITH CONFIRMED PANCREATITIS (SEE <b>WARNINGS</b>).</P> <P>LACTIC ACIDOSIS AND SEVERE HEPATOMEGALY WITH STEATOSIS, INCLUDING FATAL ASES, HAVE BEEN EPORTED WITH THE USE OF NUCLEOSIDE ANALOGUES ALONE OR IN COMBINATION, INCLUDING DIDANOSINE AND OTHER ANTIRETROVIRALS (SEE <b>WARNINGS</b>). </P> </td> </tr> </table> <br> <P>VIDEX is the brand name for didanosine (ddI), a synthetic purine nucleoside analogue active against the Human Immunodeficiency Virus (HIV). VIDEX Chewable/Dispersible Buffered Tablets are available for oral administration in strengths of 25, 50, 100, 150, and 200 mg of didanosine. Each tablet is buffered with calcium carbonate and magnesium hydroxide. VIDEX tablets also contain aspartame, sorbitol, microcrystalline cellulose, polyplasdone, mandarin-orange flavor and magnesium stearate. </P> <P>VIDEX Buffered Powder for Oral Solution is supplied for oral administration in single-dose packets containing 100, 167, or 250 mg of didanosine. Packets of each product strength also contain a citrate-phosphate buffer (composed of dibasic sodium phosphate, sodium citrate, and citric acid) and sucrose. </P> <P>VIDEX Pediatric Powder for Oral Solution is supplied for oral administration in 4- or 8-ounce glass bottles containing 2 or 4 grams of didanosine, respectively. </P> <P>The chemical name for didanosine is 2',3'-dideoxyinosine. </P> <P>Didanosine is a white crystalline powder with the molecular formula C<SUB>10</SUB>H<SUB>12</SUB>N<SUB>4</SUB>O<SUB>3</SUB> and a molecular weight of 236.2. The aqueous solubility of didanosine at 25C and pH of approximately 6 is 27.3 mg/mL. Didanosine is unstable in acidic solutions. For example, at pH <3 and 37C, 10% of didanosine decomposes to hypoxanthine in less than 2 minutes. </P>
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Duesberg on AIDS- The Risk-AIDS Hypothesis
Infectious AIDS - Have We Been Misled? This is the official HIV/AIDS research from the University of California Berkeley, Department of Molecular and Cell Biology. This contains the written research works of Professor Peter H. Duesberg on the subject, as well as other scientists that support his views, such as Kary B. Mullis, and Professor Walter Gilbert - both Nobel prize winners (Kary Mullis won the 1993 Nobel Prize in chemistry for his invention of the polymerase chain reaction technique, for detecting DNA, which is used to search for fragments of HIV in AIDS patient. Walter Gilbert, professor in molecular biology, won the 1980 Nobel prize in chemistry. This outstanding site includes scientific papers, articles, and a full text search index.
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Emtriva Online, Description, Chemistry, Ingredients - Emtricitabine - RxList Mon
Description Monographs include chemistry, chemical structure, inactive ingredients
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Entrez PubMed
PubMed is the National Library of Medicine's search service that provides access to over 11 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals.
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Nucleoside Analogues
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Nucleoside analogues and HIV: the combined cost to mitochondria -- Cherry and We
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Safety and Efficacy of Switching to Alternative Nucleoside Analogues Following S
HIVandHepatitis.com: The Internet publication with accurate, timely and cutting-edge information on treatment and vaccines for HIV / AIDS
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The Importance of HIV Medications
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